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Endocrine Abstracts

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ea0077p179 | Metabolism, Obesity and Diabetes | SFEBES2021

Impact of α-MSH on glucose tolerance in healthy participants: The first in human randomized, double-blind, placebo-controlled, physiological study

Sahar Bashar , Johnson Brett , Samarasinghe Suhaniya , Shwan Patrick , Docherty Neil , Roux Carl Le , Choudry Tasnia , Miras Alex

This abstract has been withdrawn at the request of the first author and Imperial College London. 08/06/2022...
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ea0037ep515 | Diabetes (complications & therapy) | ECE2015

Roux-en-Y gastric bypass reduces proteinuria in diabetic kidney disease to a greater extent than weight loss alone in the Zucker diabetic fatty rat without a greater improvement in renal inflammation

Neff Karl , Elliott Jessie , Jackson Sabrina , Abegg Kathrin , Corteville Caroline , Munoz Rodrigo , Docherty Neil , Lutz Thomas , le Roux Carel

Background: The effect of Roux-en-Y gastric bypass (RYGB) on diabetic kidney disease (DKD) is unclear. We used a Zucker diabetic fatty rat (ZDF) model of DKD to determine the effect of RYGB on histopathological markers of DKD, proteinuria, and MCP1 excretion.Methods: ZDF rats underwent RYGB (n=15) or sham surgery (n=14) at 18 weeks of age. Eight sham operated animals were food restricted to match the weight loss of the RYGB group (body-...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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